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KMID : 1007520090180061528
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Food Science and Biotechnology
2009 Volume.18 No. 6 p.1528 ~ p.1531
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Hypolipidemic and Antioxidative Properties of Tocotrienol-rich Fraction (TRF) Supplementation in High Fat-fed Rats
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Choi Young-Min
Lee Jun-Soo
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Abstract
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In this study, we investigated a dose-dependent hypolipidemic and antioxidant effects of tocotrienol-rich fraction (TRF) from grape seeds. After induction of hyperlipidemia for 4 weeks, rats were supplemented with different dose (5, 25, and 50 mg/kg BW/day) of TRF for 1 week. Oral administration of TRF (50 mg/kg BW/day) decreased the plasma triglyceride (TG, 162.6mg/dL), total cholesterol (TC, 83.7mg/dL), low density lipoprotein-cholesterol (LDL-C, 20.3mg/dL), malondialdehyde contents (MDA, 3.3 nmol/dL), and atherogenic index (AI, 2.0) compare to high-fat diet group. These data suggest that TRF supplementation has significant health benefits through the modulation of physiological functions that include various
atherogenic lipid profiles and antioxidative status in hyperlipidemia
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KEYWORD
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tocotrienol rich fraction, grape seed, hypolipidemic, antioxidant, high fat-fed rat
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